More than a million people are expected to descend on the British capital to celebrate half a century before Pride in London.
But public health officials have urged people not to attend if they have monkey pox symptoms or feel unwell.
Saturday marks the first time the LGBTQI event has been held since the outbreak of the pandemic, marking the 50th anniversary of the UK’s first-ever Pride parade.
The parade, which organizers have called the “largest and most inclusive event in history”, will feature a lineup of artists performing on four stages in central London.
The parade, which starts at noon local time on Saturday (9:00 pm AEST) from Hyde Park Corner, will pay tribute to the inaugural march of 1972, passing key sites of the UK’s first LGBTQI movement.
The parade lasts until 6pm (Sunday AEST 3am) and ends at Whitehall Palace.
More than 600 community groups will participate in the march, for which 30,000 people have registered to participate.
American pop star Ava Max closes the show on the stage of Trafalgar Square. Other performers include Emeli Sande, Israel’s 2018 Eurovision winner Netta, Samantha Mumba and Kat Graham.
The UK has recorded the highest number of monkeypox infections outside of Africa, with over 1000 cases reported in the current outbreak.
Scientists say anyone who is in close physical contact with a person who has monkey pox or their clothing or bedding is at risk of infection.